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Mission
The Institute for Cancer Research is a private non-profit institution founded by the Fondazione Piemontese per la Ricerca sul Cancro-Onlus (FPRC) and operated by the Fondazione del Piemonte per l'Oncologia (FPO: a joint venture between the FPRC and the Regione Piemonte). It is the seat of the Department of Oncological Sciences of the University of Torino. Its mission is to make a significant contribution to fight cancer by understanding the basics, and by providing optimal diagnostic and therapeutic services. Both basic research and clinical research are actively performed, placing the Institute at the interface between molecular biology and medicine.

The FPRC provides enduring fund raising to complete the Institute’s buildings and to support basic research.

 Highlights
 

PNASThe synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions. doi: 10.1073/pnas.0809510106

JCI - The Journal of Clinical Investigation Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models J.Clin.Invest.doi:10.1172/JCI36308

American Medical Association Journal Diagnostic Accuracy of Computed Tomographic Colonography for the Detection of Advanced Neoplasia in Individuals at Increased Risk of Colorectal Cancer. JAMA-Vol. 301 No. 23, June 17, 2009

The Journal of Clinical Investigation Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis

Myoglobin tames tumor growth and spread The Journal of Clinical Investigation: commentaries

Journal of Clinical Oncology Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer


SCIENCE
Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction
Sci. Signal., 8 December 2009


Abstract: Tumor onset and progression require the accumulation of many genetic and epigenetic lesions. In some cases, however, cancer cells rely on only one of these lesions to maintain their malignant properties, and this dependence results in tumor regression upon oncogene inactivation ("oncogene addiction"). Determining which nodes of the many networks operative in the transformed phenotype specifically mediate this response to oncogene neutralization is crucial to identifying the vulnerabili...

Next Seminars
Friday 26 February 2010
Novel regulators of integrin function and traffic in cancer
Johanna Ivaska
Monday 1 March 2010
A pseudopod-centred view of eukaryotic chemotaxis, and numerical models to test it
Robert Insall

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Institute for Cancer Research and Treatment Strada Provinciale 142 km 3,95
10060 Candiolo,Torino-Italy
tel: +390119933111 - fax +390119933225