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Mission
The Institute for Cancer Research is a private non-profit institution founded by the Fondazione Piemontese per la Ricerca sul Cancro-Onlus (FPRC) and operated by the Fondazione del Piemonte per l'Oncologia (FPO: a joint venture between the FPRC and the Regione Piemonte). It is the seat of the Department of Oncological Sciences of the University of Torino. Its mission is to make a significant contribution to fight cancer by understanding the basics, and by providing optimal diagnostic and therapeutic services. Both basic research and clinical research are actively performed, placing the Institute at the interface between molecular biology and medicine.
The FPRC provides enduring fund raising to complete the Institute’s buildings and to support basic research.

AIRC Special Program in Clinical Molecular Oncology

A translational research aimed at near term benefits to the patients. more
Highlights
  

Cancer Discovery
A molecularly annotated platform of patient-derived xenografts (xenopatients) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
A. Bertotti et al and L. Trusolino

JNCI-Journal of National Cancer Institute
Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer.
Francesca De Bacco, et al Paolo M. Comoglio and Carla Boccaccio

The Journal of Clinical Investigation
Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
Federica Di Nicolantonio et al and Alberto Bardelli


The Journal of Clinical Investigation
Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

SCIENCE SIGNALING Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction
PNAS
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.
Proc Natl Acad Sci U S A. 2011 Dec 27.
Bottos A, Martini M, Di Nicolantonio F, Comunanza V, Maione F, Minassi A, Appendino G, Bussolino F, Bardelli A.

Carcinomas are comprised of transformed epithelial cells that are supported in their growth by a dedicated neovasculature. How the genetic milieu of the epithelial compartment influences tumor angiogenesis is largely unexplored. Drugs targeted to mutant cancer genes may act not only on tumor cells but also, directly or indirectly, on the surrounding stroma. We investigated the role of the BRAF(V600E) oncogene in tumor/vessel crosstalk and analyzed the effect of the BRAF inhibitor PLX4720 on tumo...


PNAS
Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores.
Proc Natl Acad Sci USA. 2011 Oct 18;108(42):17337-42. Epub 2011 Oct 10.
Serio G, Margaria V, Jensen S, Oldani A, Bartek J, Bussolino F, Lanzetti L.

Rab5 is a small GTPase known to regulate vesicular trafficking during interphase. Here, we show that Rab5 also plays an unexpected role during mitotic progression. RNAi-mediated silencing of Rab5 caused defects in chromosome congression and extensive prometaphase delay, and it correlated with a severe reduction in the localization of the centromere-associated protein CENP-F to kinetochores. CENP-F is a component of the nuclear matrix required for chromosome congression...link

Next Seminars
Friday 29 June 2012

Prof. Glauco Souza
Friday 25 May 2012

Prof. Dr. Amparo Acker-Palmer


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Institute for Cancer Research and Treatment Strada Provinciale 142 km 3,95 10060 Candiolo,Torino-Italy
tel: +390119933111 - fax +390119933225